Sandip Kaledhonka | Biomedical and Healthcare Applications | Research Excellence Award

Published on by Computer Vision Awards

Assoc. Prof. Dr. Sandip Kaledhonka | Biomedical and Healthcare Applications | Research Excellence Award

Associate professor | Indian Institute of Technology Bombay | India 

Dr. Sandip Kaledhonka is an accomplished structural biologist whose research focuses on time-resolved cryogenic electron microscopy (cryo-EM), ribosome dynamics, and molecular mechanisms underlying protein synthesis. With 38 published research documents 775 citations, an h-index of 10, and an i10-index of 10, he has established a strong global research presence through high-impact publications and sustained collaborations with leading scientists across structural biology biophysics and molecular microbiology.Dr. Kaledhonkar’s research has significantly advanced the understanding of dynamic events in translation initiation, elongation, termination, and ribosome recycling. His landmark work Late steps in bacterial translation initiation visualized using time-resolved cryo-EM published in Nature revealed critical structural intermediates that define the kinetics of ribosomal assembly. He has also contributed foundational methods including the widely used microfluidic spraying-plunging technique for ultrafast sample preparation enabling real-time visualization of rapid biochemical reactions.A notable aspect of his research is the integration of mixing-spraying microfluidics with high-resolution cryo-EM an approach that has provided unprecedented insights into transient conformations of biological macromolecules. His studies on ribosome subunit association release-factor activation and ribosome recycling published in journals such as Structure and Biophysical Journalhave shaped current understanding of translation control and fidelity. His contributions extend to photobiology with influential work on photoactive yellow protein (PYP) focusing on chromophore isomerization protonation hydrogen bonding networks and signaling kinetics.Beyond ribosome biology Dr. Kaledhonkar has collaborated on impactful multidisciplinary research including bacteriophage characterization microbial biofilm reduction structural components of jumbo phages and mechanisms of innate antimicrobial defense involving AAA-ATPases. His recent works further explore methodological innovations in cryo-EM pose estimation extracellular vesicle isolation and enzyme conformational regulation highlighting his broad scientific influence.He has co-authored publications with leading researchers such as Joachim Frank Ziao Fu Bo Chen Måns Ehrenberg and Robert A. Grassucci underscoring a strong record of international collaboration. With expertise spanning structural dynamics microfluidics and time-resolved structural biology Dr. Kaledhonkar’s research continues to contribute to the global advancement of molecular and biomedical sciences offering foundational knowledge that drives future therapeutic and biotechnological innovations.

Profiles:  Googlescholar | Scopus

Featured Publications

1. Horst, M. A., Stalcup, T. P., Kaledhonkar, S., Kumauchi, M., Hara, M., & Xie, A. (2009). Locked chromophore analogs reveal that photoactive yellow protein regulates biofilm formation in the deep sea bacterium Idiomarina loihiensis. Journal of the American Chemical Society, 131(47), 17443–17451. Cited By : 61

2. Kaledhonkar, S., Fu, Z., White, H., & Frank, J. (2018). Time-resolved cryo-electron microscopy using a microfluidic chip. In Protein Complex Assembly: Methods and Protocols (pp. 59–71). Humana Press. Cited By : 52

3. Kumauchi, M., Kaledhonkar, S., Philip, A. F., Wycoff, J., Hara, M., Li, Y., & Xie, A. (2010). A conserved helical capping hydrogen bond in PAS domains controls signaling kinetics in the superfamily prototype photoactive yellow protein. Journal of the American Chemical Society, 132(44), 15820–15830. Cited By : 12

4. Das, S., & Kaledhonkar, S. (2024). Physiochemical characterization of a potential Klebsiella phage MKP-1 and analysis of its application in reducing biofilm formation. Frontiers in Microbiology, 15, 1397447. Cited By : 3

5. Ghosh, S., Roy, S., Baid, N., Das, U. K., Rakshit, S., Sanghavi, P., Hajra, D., Das, S., … & (include remaining authors if available). (2025). Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence. Nature Microbiology, 1–16. Cited By : 2

Dr. Kaledhonkar’s pioneering time-resolved cryo-EM work reveals molecular events in real time, advancing fundamental understanding of translation mechanisms. His innovations in microfluidic methodology continue to transform structural biology and accelerate discoveries in molecular medicine.

Shenglin Wang | Biomedical and Healthcare Applications | Young Scientist Award

Published on by Computer Vision Awards

Dr. Shenglin Wang | Biomedical and Healthcare Applications | Young Scientist Award

Clinician-Scientist | Fujian Medical University | China

Dr. Shenglin Wang is a biomedical researcher whose work focuses on tumor biology, cancer metastasis, and molecular mechanisms underlying osteosarcoma, chondrosarcoma, and lung cancer bone lesions. He completed a Post-doctoral Fellowship at Fujian Medical University where he advanced single-cell sequencing, tumor microenvironment profiling, and molecular pathology research. In 2025, he joined The First Affiliated Hospital of Fujian Medical University as a Physician, continuing to integrate clinical oncology with translational cancer research.Over the last five years, Dr. Wang has secured three competitive research grants as Principal Investigator or Co-Investigator. His ongoing NSFC project  investigates SOX18-mediated endothelial senescence and HBEGF secretion in non-small cell lung cancer bone metastasis, aiming to define novel therapeutic targets within the senescent vascular niche. He also leads a provincial project exploring HMGA2-regulated ferroptosis resistance in chondrosarcoma, contributing to the understanding of tumor progression and cell death mechanisms. His completed NSFC project, focused on aptamer-based electrochemical sensing for rapid detection of circulating tumor cells, reflects his multidisciplinary approach combining bioengineering with oncology.Dr. Wang has authored 33 peer-reviewed publications, accumulating 651 citations, with an h-index of 11, demonstrating sustained research productivity and academic impact. His representative articles include studies in Cell Proliferation, Frontiers in Immunology, and Acta Biochimica et Biophysica Sinica, covering topics such as single-cell transcriptomics of metastatic bone microenvironments, immune regulatory networks in thyroid carcinoma, and STAT3/EGFR signaling in osteosarcoma drug resistance. His collaborative work spans more than 60 co-authors, highlighting strong interdisciplinary engagement.Collectively, Dr. Wang’s research advances understanding of tumor microenvironment remodeling, therapeutic resistance, and metastasis-associated cell senescence. His contributions support the development of precision oncology strategies and have broad implications for improving diagnostic, prognostic, and therapeutic outcomes in bone-related malignancies.

Profiles:  Scopus | ResearchGate

Featured Publications

1. Author(s). (2025). The integrin α2–osteoclast axis: A key driver of bone destruction and therapeutic target in osteosarcoma. Journal of Translational Medicine.

2. Author(s). (2021). Corrigendum: Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway. Acta Biochimica et Biophysica Sinica, 53(12), 1670–1680.

3. Author(s). (2025). Single-cell transcriptomic analysis of the senescent microenvironment in bone metastasis. Cell Proliferation, 58(1), e13743. Cited By : 5

The nominee’s work advances precision oncology by uncovering key molecular and microenvironmental mechanisms that drive tumor progression, therapeutic resistance, and bone metastasis, enabling the development of more effective diagnostic and therapeutic strategies. By integrating single-cell analytics, molecular signaling research, and translational innovation, the nominee contributes to improved cancer outcomes and supports global efforts toward personalized, mechanism-driven cancer care.

Alina Diana Zamfir | Biomedical and Healthcare Applications | Best Researcher Award

Published on by Computer Vision Awards

Prof. Alina Diana Zamfir | Biomedical and Healthcare Applications | Best Researcher Award

Professor |  National Institute for R&D in Electrochemistry | Romania

Prof. Dr. Alina D. Zamfir is a leading Romanian scientist recognized internationally for her pioneering research in mass spectrometry, glycomics, proteomics, and structural biology. She currently holds dual appointments as Senior Scientific Researcher at the National Institute for Research and Development in Electrochemistry and Condensed Matter Research, Timisoara, and as Professor at Aurel Vlaicu University of Arad, Romania. she has also served as a PhD Supervisor at the Faculty of Physics, West University of Timisoara, mentoring numerous young scientists in advanced analytical methodologies.Prof. Zamfir’s research has made seminal contributions to the development of advanced mass spectrometry platforms, particularly in the integration of microfluidics, ion mobility, and nanoelectrospray systems for glycoproteomics and glycolipidomics. She has been the Principal Investigator of 17 national and international projects, funded by the Romanian UEFISCDI and the European Union, focusing on the structural and functional elucidation of complex biological molecules, including gangliosides and proteoglycans. Her collaborations extend across prestigious institutions such as the University of Münster, University of Konstanz (Germany), and Clarkson University (USA), contributing significantly to global biomedical research.Author of 198 peer-reviewed publications with over 3,018 citations and an h-index of 37, Prof. Zamfir’s work has appeared in high-impact journals including Analytical Chemistry, Electrophoresis, Glycobiology, and the Journal of the American Society for Mass Spectrometry. She has also served as Guest Editor for Molecules and Frontiers in Molecular Biosciences and as President of the Romanian Society for Mass Spectrometry since 2009, promoting the advancement of analytical sciences in Romania and beyond.Through her academic leadership, editorial contributions, and innovative research, Prof. Zamfir has profoundly influenced modern bioanalytical chemistry, driving forward applications in biomarker discovery, neurodegenerative disease research, and precision medicine. Her work bridges fundamental science and societal impact, advancing both Romania’s scientific excellence and the global progress of molecular biosciences.

Profiles: Google Scholar | ResearchGate

Featured Publications

1, Zamfir, A. D. (2007). Recent advances in sheathless interfacing of capillary electrophoresis and electrospray ionization mass spectrometry. Journal of Chromatography A, 1159(1–2), 2–13. Cited By : 117

2. Zamfir, A., Vakhrushev, S., Sterling, A., Niebel, H. J., Allen, M., & Peter-Katalinić, J. (2004). Fully automated chip-based mass spectrometry for complex carbohydrate system analysis. Analytical Chemistry, 76(7), 2046–2054.
Cited By : 94

3. Sarbu, M., Robu, A. C., Ghiulai, R. M., Vukelić, Z., Clemmer, D. E., & Zamfir, A. D. (2016). Electrospray ionization ion mobility mass spectrometry of human brain gangliosides. Analytical Chemistry, 88(10), 5166–5178. Cited By : 81

4. Sisu, E., Flangea, C., Serb, A., & Zamfir, A. D. (2011). Modern developments in mass spectrometry of chondroitin and dermatan sulfate glycosaminoglycans. Amino Acids, 41(2), 235–256. Cited By : 68

5. Zamfir, A. D., Bindila, L., Lion, N., Allen, M., Girault, H. H., & Peter-Katalinić, J. (2005). Chip electrospray mass spectrometry for carbohydrate analysis. Electrophoresis, 26(19), 3650–3673.* Cited By : 66

Dr. Khadijah Dashti | Biomedical and Healthcare Applications | Best Researcher Award

Published on by Computer Vision Awards

Dr. Khadijah Dashti | Biomedical and Healthcare Applications | Best Researcher Award

Doctorate at Kuwait University | Kuwait

Dr. Khadijah Mohammed Dashti is a distinguished academic and researcher in the field of Medical Microbiology and Antimicrobial Agents. She currently serves as an Assistant Professor at the Faculty of Allied Health Sciences, Kuwait University, where she has been a faculty member since 2023. With extensive expertise in microbial diseases and innovative approaches to antibiotic discovery, Dr. Dashti is a leading figure in her field.

Professional Profile

Scopus

🎓Academic Qualifications 

Dr. Khadijah Mohammed Dashti holds a rich academic background in Medical Laboratory Sciences and Biomedical Sciences. She completed her Bachelor’s Degree (B.Sc.) in Medical Laboratory Sciences at Kuwait University in 2011, where her research project investigated “The prevalence of plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli in Kuwait.”Her academic journey continued with two Master’s Degrees (M.Sc.). The first, in Biomedical Sciences, was awarded by the University of Westminster in 2015, with her thesis focusing on “The effect of heavy metals on biofilm formed by Pseudomonas aeruginosa.” The second, in Medical Laboratory Sciences, was earned at Kuwait University in 2016, and her thesis explored “The Prevalence of Multidrug-resistant Acinetobacter baumannii in Kuwait and Typing of the Isolates by MLST.”

Dr. Dashti achieved her Ph.D. in Microbial Diseases and Antimicrobial Agents from University College London in 2023. Her doctoral research, titled “Natural Antibiotic Discovery,” reflects her profound dedication to finding innovative solutions to combat antimicrobial resistance.

🧪Academic Experience and Achievements 

Dr. Dashti has been actively involved in academic mentorship, having supervised four B.Sc. student projects since 2023. These projects explored diverse topics such as the antibacterial potential of colistin-resistant Escherichia coli, the use of garlic and essential oils in combating resistance, and the discovery of novel antibacterials by mining Pseudomonas aeruginosa genomes. Her guidance and expertise have fostered critical research in microbial sciences.She has also attended and benefited from workshops such as the Bioinformatics course and the How to Write a Good Dissertation/Thesis session, both presented by Prof. Sebastian Amyes at Kuwait University, further enhancing her academic and mentorship capabilities.

🔬Research Interests 

Dr. Dashti’s research interests center on understanding and combating pathogenic microorganisms and antibiotic resistance. She investigates the mechanisms of drug resistance in critical pathogens such as Staphylococci/MRSA and ESKAPE pathogens, aiming to develop novel antibacterial methods. Her work also delves into understanding host-bacteria interactions, focusing on their dynamics in health and disease. A key area of her current research is the identification of new sources of antibiotic-producing bacteria to address global challenges in infectious disease treatment.

🌍Memberships and Affiliations 

A dedicated professional, Dr. Dashti is an active member of the Society for Applied Microbiology (SfAM) and the Microbiology Society, maintaining her affiliation with both organizations since 2016.

🧠Skills and Expertise 

Dr. Dashti possesses advanced skills in bioinformatics, antimicrobial resistance, and microbial pathogenicity. Her strong expertise in antibiotic discovery and development of novel antibacterial techniques underscores her commitment to addressing infectious diseases. Furthermore, her proficiency in academic supervision, research project guidance, and publication of high-quality research demonstrates her multifaceted expertise in microbial sciences.Dr. Khadijah Mohammed Dashti’s significant contributions to antimicrobial research and her dedication to mentoring future scientists make her an inspiring figure in the field of microbiology.

Publications Top Noted📚

Genetic landscape and clinical outcomes of autosomal recessive polycystic kidney disease in Kuwait

Authors: Alhaddad, M.E., Mohammad, A., Dashti, K.M., Al-Ali, M., Ali, H.
Journal: Heliyon
Year: 2024

Diversity of multi-drug resistant Acinetobacter baumannii population in a major hospital in Kuwait

Authors: Vali, L., Dashti, K., Opazo-Capurro, A.F., Al Obaid, K., Evans, B.A.
Journal: Frontiers in Microbiology
Year: 2015