Xiangu Chen | Biomedical and Healthcare Applications | Best Research Article Award

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Prof. Xianguo Chen | Biomedical and Healthcare Applications | Best Research Article Award

Professor | Zhejiang University School of Medicine | China

Dr. Xianguo Chen is an active researcher in the field of lung cancer biology, molecular oncology, and precision medicine, with a strong focus on exploring genetic alterations, therapeutic resistance mechanisms, and biomarker-driven clinical translation. Affiliated with the Zhejiang University School of Medicine, Dr. Chen has established a robust research portfolio, contributing 16 scientific publications, accumulating 48 citations, and maintaining an h-index of 4, reflecting consistent scholarly impact within a rapidly evolving biomedical landscape.Dr. Chen’s research spans critical areas of lung adenocarcinoma, non-small cell lung cancer (NSCLC), oncogenic signaling pathways, and clinical molecular diagnostics. His work includes multiple contributions as first author, corresponding author, and co-corresponding author, demonstrating scientific leadership and collaboration across multidisciplinary teams. Notable publications include studies on miR-1293–mediated angiogenesis regulation, carbonic anhydrase 4 as a prognostic biomarker, and the identification of novel RET and ALK fusions in NSCLC, each contributing valuable insights into cancer progression, heterogeneity, and precision-targeted therapy.His commitment to translational oncology is further reflected in several research grants. These include major funded projects focused on acacetin-mediated SMYD2 inhibition and DNA damage repair, KMT3C-driven osimertinib resistance via ENO1-regulated glycolysis, and metabolomic discrimination of pulmonary nodules combined with fecal microbiota transplantation strategies. These funded studies highlight his expertise in integrating molecular biology, bioinformatics, and therapeutic research to address pressing clinical challenges in cancer diagnosis and treatment.In addition to his publication record, Dr. Chen engages in collaborative research involving over 130 co-authors, demonstrating broad interdisciplinary partnerships across medical, molecular, and computational sciences. His recent article on machine learning–based immune prognosis modeling for lung adenocarcinoma extends his contributions into the domain of AI-assisted oncology, reinforcing the relevance of computational technologies in modern cancer research.Dr. Chen’s scientific efforts collectively aim to enhance early cancer detection, refine prognostic tools, and illuminate new molecular targets for therapy. Through his funded projects, high-quality publications, and sustained collaborative activity, he continues to contribute significantly to the advancement of global lung cancer research and its transition toward more personalized, mechanism-driven clinical care.

Profiles: Scopus | ResearchGate

Featured Publication

1.Construction and validation of immune prognosis model for lung adenocarcinoma based on machine learning. (2025). Frontiers in Oncology.

Dr. Xianguo Chen research advances precision oncology by uncovering molecular mechanisms that drive lung cancer progression and therapeutic resistance, enabling more accurate diagnostics and targeted treatment strategies.

Sandip Kaledhonka | Biomedical and Healthcare Applications | Research Excellence Award

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Assoc. Prof. Dr. Sandip Kaledhonka | Biomedical and Healthcare Applications | Research Excellence Award

Associate professor | Indian Institute of Technology Bombay | India 

Dr. Sandip Kaledhonka is an accomplished structural biologist whose research focuses on time-resolved cryogenic electron microscopy (cryo-EM), ribosome dynamics, and molecular mechanisms underlying protein synthesis. With 38 published research documents 775 citations, an h-index of 10, and an i10-index of 10, he has established a strong global research presence through high-impact publications and sustained collaborations with leading scientists across structural biology biophysics and molecular microbiology.Dr. Kaledhonkar’s research has significantly advanced the understanding of dynamic events in translation initiation, elongation, termination, and ribosome recycling. His landmark work Late steps in bacterial translation initiation visualized using time-resolved cryo-EM published in Nature revealed critical structural intermediates that define the kinetics of ribosomal assembly. He has also contributed foundational methods including the widely used microfluidic spraying-plunging technique for ultrafast sample preparation enabling real-time visualization of rapid biochemical reactions.A notable aspect of his research is the integration of mixing-spraying microfluidics with high-resolution cryo-EM an approach that has provided unprecedented insights into transient conformations of biological macromolecules. His studies on ribosome subunit association release-factor activation and ribosome recycling published in journals such as Structure and Biophysical Journalhave shaped current understanding of translation control and fidelity. His contributions extend to photobiology with influential work on photoactive yellow protein (PYP) focusing on chromophore isomerization protonation hydrogen bonding networks and signaling kinetics.Beyond ribosome biology Dr. Kaledhonkar has collaborated on impactful multidisciplinary research including bacteriophage characterization microbial biofilm reduction structural components of jumbo phages and mechanisms of innate antimicrobial defense involving AAA-ATPases. His recent works further explore methodological innovations in cryo-EM pose estimation extracellular vesicle isolation and enzyme conformational regulation highlighting his broad scientific influence.He has co-authored publications with leading researchers such as Joachim Frank Ziao Fu Bo Chen Måns Ehrenberg and Robert A. Grassucci underscoring a strong record of international collaboration. With expertise spanning structural dynamics microfluidics and time-resolved structural biology Dr. Kaledhonkar’s research continues to contribute to the global advancement of molecular and biomedical sciences offering foundational knowledge that drives future therapeutic and biotechnological innovations.

Profiles:  Googlescholar | Scopus

Featured Publications

1. Horst, M. A., Stalcup, T. P., Kaledhonkar, S., Kumauchi, M., Hara, M., & Xie, A. (2009). Locked chromophore analogs reveal that photoactive yellow protein regulates biofilm formation in the deep sea bacterium Idiomarina loihiensis. Journal of the American Chemical Society, 131(47), 17443–17451. Cited By : 61

2. Kaledhonkar, S., Fu, Z., White, H., & Frank, J. (2018). Time-resolved cryo-electron microscopy using a microfluidic chip. In Protein Complex Assembly: Methods and Protocols (pp. 59–71). Humana Press. Cited By : 52

3. Kumauchi, M., Kaledhonkar, S., Philip, A. F., Wycoff, J., Hara, M., Li, Y., & Xie, A. (2010). A conserved helical capping hydrogen bond in PAS domains controls signaling kinetics in the superfamily prototype photoactive yellow protein. Journal of the American Chemical Society, 132(44), 15820–15830. Cited By : 12

4. Das, S., & Kaledhonkar, S. (2024). Physiochemical characterization of a potential Klebsiella phage MKP-1 and analysis of its application in reducing biofilm formation. Frontiers in Microbiology, 15, 1397447. Cited By : 3

5. Ghosh, S., Roy, S., Baid, N., Das, U. K., Rakshit, S., Sanghavi, P., Hajra, D., Das, S., … & (include remaining authors if available). (2025). Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence. Nature Microbiology, 1–16. Cited By : 2

Dr. Kaledhonkar’s pioneering time-resolved cryo-EM work reveals molecular events in real time, advancing fundamental understanding of translation mechanisms. His innovations in microfluidic methodology continue to transform structural biology and accelerate discoveries in molecular medicine.

Shenglin Wang | Biomedical and Healthcare Applications | Young Scientist Award

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Dr. Shenglin Wang | Biomedical and Healthcare Applications | Young Scientist Award

Clinician-Scientist | Fujian Medical University | China

Dr. Shenglin Wang is a biomedical researcher whose work focuses on tumor biology, cancer metastasis, and molecular mechanisms underlying osteosarcoma, chondrosarcoma, and lung cancer bone lesions. He completed a Post-doctoral Fellowship at Fujian Medical University where he advanced single-cell sequencing, tumor microenvironment profiling, and molecular pathology research. In 2025, he joined The First Affiliated Hospital of Fujian Medical University as a Physician, continuing to integrate clinical oncology with translational cancer research.Over the last five years, Dr. Wang has secured three competitive research grants as Principal Investigator or Co-Investigator. His ongoing NSFC project  investigates SOX18-mediated endothelial senescence and HBEGF secretion in non-small cell lung cancer bone metastasis, aiming to define novel therapeutic targets within the senescent vascular niche. He also leads a provincial project exploring HMGA2-regulated ferroptosis resistance in chondrosarcoma, contributing to the understanding of tumor progression and cell death mechanisms. His completed NSFC project, focused on aptamer-based electrochemical sensing for rapid detection of circulating tumor cells, reflects his multidisciplinary approach combining bioengineering with oncology.Dr. Wang has authored 33 peer-reviewed publications, accumulating 651 citations, with an h-index of 11, demonstrating sustained research productivity and academic impact. His representative articles include studies in Cell Proliferation, Frontiers in Immunology, and Acta Biochimica et Biophysica Sinica, covering topics such as single-cell transcriptomics of metastatic bone microenvironments, immune regulatory networks in thyroid carcinoma, and STAT3/EGFR signaling in osteosarcoma drug resistance. His collaborative work spans more than 60 co-authors, highlighting strong interdisciplinary engagement.Collectively, Dr. Wang’s research advances understanding of tumor microenvironment remodeling, therapeutic resistance, and metastasis-associated cell senescence. His contributions support the development of precision oncology strategies and have broad implications for improving diagnostic, prognostic, and therapeutic outcomes in bone-related malignancies.

Profiles:  Scopus | ResearchGate

Featured Publications

1. Author(s). (2025). The integrin α2–osteoclast axis: A key driver of bone destruction and therapeutic target in osteosarcoma. Journal of Translational Medicine.

2. Author(s). (2021). Corrigendum: Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway. Acta Biochimica et Biophysica Sinica, 53(12), 1670–1680.

3. Author(s). (2025). Single-cell transcriptomic analysis of the senescent microenvironment in bone metastasis. Cell Proliferation, 58(1), e13743. Cited By : 5

The nominee’s work advances precision oncology by uncovering key molecular and microenvironmental mechanisms that drive tumor progression, therapeutic resistance, and bone metastasis, enabling the development of more effective diagnostic and therapeutic strategies. By integrating single-cell analytics, molecular signaling research, and translational innovation, the nominee contributes to improved cancer outcomes and supports global efforts toward personalized, mechanism-driven cancer care.

Ateke Goshvarpour | Biomedical and Healthcare Applications | Editorial Board Member

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Assist. Prof. Dr. Ateke Goshvarpour | Biomedical and Healthcare Applications | Editorial Board Member

Assistant Professor | Imam Reza International University | Iran

Dr. Ateke Goshvarpour, affiliated with Imam Reza International University, Mashhad, Iran, is a distinguished researcher specializing in biomedical signal processing, cognitive neuroscience, and computational modeling of brain activity. With a prolific research portfolio comprising 70 publications and over 1,095 citations across 727 scholarly documents, Dr. Goshvarpour has established a strong global reputation for her contributions to the understanding and classification of cognitive and mental disorders using advanced signal analysis techniques.Her recent works focus on EEG-based diagnosis of schizophrenia, emotion recognition, and cognitive assessment, integrating concepts from quantum-inspired computation, chaotic dynamics, and neural connectivity analysis. Notable studies such as “Enhancing Schizophrenia Diagnosis through EEG Frequency Waves and Information-Based Neural Connectivity Feature Fusion” and “Quantum-Inspired Feature Extraction Model for Enhanced Schizophrenia Detection” highlight her innovative approach in bridging neuroscience with machine learning and chaos theory. Through the development of spectral–spatiotemporal models and graph-based signal representations, she provides novel pathways for noninvasive brain disorder diagnostics and affective computing.Collaborating with a network of 21 co-authors, Dr. Goshvarpour demonstrates an interdisciplinary outlook, integrating engineering, data science, and psychology to improve diagnostic precision and healthcare outcomes. Her h-index of 20 reflects both the impact and consistency of her research influence. Beyond academia, her work contributes significantly to societal well-being by enabling early and accurate detection of neurological conditions and enhancing emotional intelligence systems.Dr. Goshvarpour’s dedication to advancing the frontier of biomedical and cognitive signal processing underscores her role as a leading figure in computational neuroscience research, fostering a deeper understanding of human cognition through data-driven and bio-inspired intelligence frameworks.

Profiles: ORCID |  Scopus | Google Scholar

Featured Publications

1.Goshvarpour, A. (2025). Enhancing schizophrenia diagnosis through EEG frequency waves and information-based neural connectivity feature fusion. Biomedical Signal Processing and Control.

2.Goshvarpour, A. (2025). Quantum-inspired feature extraction model from EEG frequency waves for enhanced schizophrenia detection. Chaos, Solitons & Fractals. Cited By : 1

3.Goshvarpour, A. (2025). Cognitive-inspired spectral spatiotemporal analysis for emotion recognition utilizing electroencephalography signals. Cognitive Computation. Cited By : 4

4.Goshvarpour, A. (2025). Asymmetric measures of polar Chebyshev chaotic map for discrete/dimensional emotion recognition using PPG. Biomedical Signal Processing and Control. Cited By : 1

5.Goshvarpour, A. (2025). Diagnosis of cognitive and mental disorders: A new approach based on spectral–spatiotemporal analysis and local graph structures of electroencephalogram signals. Brain Sciences. Cited By : 3

Dr. Ateke Goshvarpour’s pioneering research in biomedical signal processing and neurocomputational modeling is transforming the early detection of mental and cognitive disorders. By integrating EEG analytics, chaos theory, and AI-driven methods, her work bridges neuroscience and technology—advancing precision diagnostics, enhancing emotional intelligence systems, and fostering global innovation in digital health and mental well-being.

Alina Diana Zamfir | Biomedical and Healthcare Applications | Best Researcher Award

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Prof. Alina Diana Zamfir | Biomedical and Healthcare Applications | Best Researcher Award

Professor |  National Institute for R&D in Electrochemistry | Romania

Prof. Dr. Alina D. Zamfir is a leading Romanian scientist recognized internationally for her pioneering research in mass spectrometry, glycomics, proteomics, and structural biology. She currently holds dual appointments as Senior Scientific Researcher at the National Institute for Research and Development in Electrochemistry and Condensed Matter Research, Timisoara, and as Professor at Aurel Vlaicu University of Arad, Romania. she has also served as a PhD Supervisor at the Faculty of Physics, West University of Timisoara, mentoring numerous young scientists in advanced analytical methodologies.Prof. Zamfir’s research has made seminal contributions to the development of advanced mass spectrometry platforms, particularly in the integration of microfluidics, ion mobility, and nanoelectrospray systems for glycoproteomics and glycolipidomics. She has been the Principal Investigator of 17 national and international projects, funded by the Romanian UEFISCDI and the European Union, focusing on the structural and functional elucidation of complex biological molecules, including gangliosides and proteoglycans. Her collaborations extend across prestigious institutions such as the University of Münster, University of Konstanz (Germany), and Clarkson University (USA), contributing significantly to global biomedical research.Author of 198 peer-reviewed publications with over 3,018 citations and an h-index of 37, Prof. Zamfir’s work has appeared in high-impact journals including Analytical Chemistry, Electrophoresis, Glycobiology, and the Journal of the American Society for Mass Spectrometry. She has also served as Guest Editor for Molecules and Frontiers in Molecular Biosciences and as President of the Romanian Society for Mass Spectrometry since 2009, promoting the advancement of analytical sciences in Romania and beyond.Through her academic leadership, editorial contributions, and innovative research, Prof. Zamfir has profoundly influenced modern bioanalytical chemistry, driving forward applications in biomarker discovery, neurodegenerative disease research, and precision medicine. Her work bridges fundamental science and societal impact, advancing both Romania’s scientific excellence and the global progress of molecular biosciences.

Profiles: Google Scholar | ResearchGate

Featured Publications

1, Zamfir, A. D. (2007). Recent advances in sheathless interfacing of capillary electrophoresis and electrospray ionization mass spectrometry. Journal of Chromatography A, 1159(1–2), 2–13. Cited By : 117

2. Zamfir, A., Vakhrushev, S., Sterling, A., Niebel, H. J., Allen, M., & Peter-Katalinić, J. (2004). Fully automated chip-based mass spectrometry for complex carbohydrate system analysis. Analytical Chemistry, 76(7), 2046–2054.
Cited By : 94

3. Sarbu, M., Robu, A. C., Ghiulai, R. M., Vukelić, Z., Clemmer, D. E., & Zamfir, A. D. (2016). Electrospray ionization ion mobility mass spectrometry of human brain gangliosides. Analytical Chemistry, 88(10), 5166–5178. Cited By : 81

4. Sisu, E., Flangea, C., Serb, A., & Zamfir, A. D. (2011). Modern developments in mass spectrometry of chondroitin and dermatan sulfate glycosaminoglycans. Amino Acids, 41(2), 235–256. Cited By : 68

5. Zamfir, A. D., Bindila, L., Lion, N., Allen, M., Girault, H. H., & Peter-Katalinić, J. (2005). Chip electrospray mass spectrometry for carbohydrate analysis. Electrophoresis, 26(19), 3650–3673.* Cited By : 66

Biomedical and Healthcare Applications

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Introduction of Biomedical and Healthcare Applications

Biomedical and Healthcare Applications research encompasses a wide spectrum of scientific and technological endeavors aimed at improving healthcare, medical diagnostics, treatments, and patient outcomes. This multidisciplinary field harnesses the power of cutting-edge technology and innovative approaches to address the complex challenges faced by healthcare professionals and patients alike.

Subtopics in Biomedical and Healthcare Applications:

  1. Medical Imaging and Analysis: This subfield focuses on advancing techniques for medical imaging modalities such as MRI, CT scans, and ultrasound. Researchers work on image processing, computer-aided diagnosis, and developing AI algorithms to aid in early disease detection and treatment planning.
  2. Telemedicine and Remote Monitoring: Research in telemedicine explores ways to provide healthcare services remotely, making it more accessible, especially in underserved areas. Remote monitoring involves wearable devices and IoT technologies to track patient health in real-time.
  3. Biomedical Sensors and Devices: Scientists develop innovative sensors and medical devices for diagnostics, therapy, and monitoring, including wearable health trackers, smart prosthetics, and drug delivery systems.
  4. Genomic Medicine and Personalized Healthcare: Genomic research seeks to understand the genetic basis of diseases and develop personalized treatment plans based on individual genetic profiles.
  5. Healthcare Data Analytics and Machine Learning: Researchers in this subtopic analyze healthcare data to extract valuable insights, improve clinical decision-making, and develop predictive models for disease prevention and management.
  6. Medical Robotics and Surgery: Advancements in medical robotics enhance surgical precision, minimize invasiveness, and enable remote surgeries. Research focuses on developing robotic systems for various medical procedures.
  7. Pharmaceutical Research and Drug Discovery: In this area, scientists work on discovering new drugs, optimizing existing ones, and developing targeted therapies to improve patient outcomes.
  8. Rehabilitation and Assistive Technologies: Research in rehabilitation involves the development of technologies and therapies to aid individuals with disabilities, such as robotic exoskeletons and brain-computer interfaces.
  9. Healthcare Policy and Health Informatics: This subfield explores the intersection of healthcare, information technology, and policy to improve healthcare delivery, patient safety, and regulatory compliance.
  10. Global Health and Infectious Disease Control: Researchers work on solutions to address global health challenges, including infectious disease outbreaks, vaccine development, and healthcare infrastructure in low-resource settings.

Biomedical and Healthcare Applications research plays a crucial role in shaping the future of healthcare, making it more accessible, efficient, and effective. These subtopics represent the diverse and impactful areas of study within this field.

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